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Is using TStringList to load huge text file the best way in Delphi?

However, efficiency in data manipulation may not be that much of an issue, as you are using text files to hold a database. If you just need to read in and make decisions based on data in the file, the more flexible TList may be overkill.

I doubt the length of text on each line is fixed; The OP says It contains 150 field with each at least 50 characters. I think the fix quantity is the number of fields.

Since you have a fixed length that you're working with, you can build an access class based on TList with a TWriter and TReader that will take your records into account. You'll have none of the overhead of a TStringList (not that it's a bad thing, but if you don't need it, why have it) and you can build in your own access to records into the class. Ultimately it depends on what you are trying to accomplish with the data once you have it loaded into memory. While TStringlist is easy to use, it isn't as efficient as "rolling your own".